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Desvenlafaxine (immediate-release) has a short half-life of 11 hours, 8 but Pristiq is contained in a time-release format designed to release over a 24-hour period Hello, I am here for you and am happy to respond. Recommended Gina Hughes Former Psychiatric Nurse Practitioner Author has 5. My dosage of Pristiq was dropped to 25 MG from 50 MG and I ran out of the 25MG pills. If you want to be absolutely sure you can always ask your pharmacist. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved. It should have a little place on the pill where to cut it. My Dr is extremely hard to get on the phone, and at the time I didn't think to ask, I had so much else going on. I read online (after the fact) that its a time release pill that should never be cut on half. I already have bad side effects but feeling worse These tablets cannot be cut, split, or crushed without making the drug immediate-release. 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Read More I don't mean to patronise you in case you're already aware of this but just in case you're not The tablets can be cut in half when needed providing a 12. In clinical studies, doses of 10 mg to 400 mg per day were studied Is it safe to cut pristiq tablets in half. Therefore by breaking the pill , it may cause too much of the drug to be released at one time. Pick up a pill cutter at your pharmacy which will make halving them easier and more accurate. I already have bad side effects but feeling worse Pristiq has a very short half life, about 12 hours, compared to other antidepressants which is why it’s important to take it at the SAME TIME every day to avoid any side effects. Anyone have experience with this issue? My pill has a "divit" like a divider already so it cut very easily. Please ask your ned prescriber or pharmacist about the advisability before trying this He uped my dose of pristiq to 75mg cutting a pills n half. 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